Yes. In any major countries, they can refuse an applicant with diseases that will need lots of hospitalization. Example, if you’re in stage 4 cancer. They can refuse your application since Canada won’t benefit from you anyway and will even spend money for your hospital bills. The only reason that Canada wants you here is they can benefit from you by your contribution in the economy like paying taxes.
My sister before was delayed because her medical result had TB exposure (well, ALL FILIPINOS has been exposed to TB patients). She had to take medical again after 6 months treatment to be approved. If one of your dependents has a major disease like kidney failure, they would need dialysis often, so it is also subject for refusal. (Not all canadians are willing to “adopt” a person from other countries and pay his hospital bills. I also have to pay bills and help my own family. Where do you think Canada will get his payment for hospital bills? From our own pocket thru tax!)
Another way of refusal is when you have a CRIMINAL RECORD. So regardless if you passed all eligibility and medical, they can refuse someone who can eventually commit a crime here. So having a PAOR and medical request is NOT a guarantee that you will be approved. Canada is a working place NOT an orphanage.