Your uncle doesn't qualify to sponsor you since he's living in Quebec. However assuming he's actually living in Canada (rather that a citizen living outside of the country), you will get additional "adaptability" points if you apply as a skilled worker. To get these adaptability points, you will need to supply proof that he is in fact your uncle and evidence that he is living in Canada (bills, tax returns, etc.). So you'll need his involvement / assistance to get these points.
I'm not sure what you mean by "landed on my own and only use his address as a reference point". Your first step will be to determine which immigration category you qualify under (I would look at federal skilled worker and the provincial nominee programs). Once you've done this and determined how to apply, you will submit a completed application for processing. This is something you would do from the US (no need to be in Canada). Even if your wife and children are not accompanying you, they will still have to be medically examined as part of the application process (this is mandatory). If you want to claim adaptability points for having family in Canada, you will need to work with your uncle to include the required supporting documentation in your original application package.
Once your application has been processed and presumably approved, you will then land in Canada as a permament resident.
Note that to qualify for the federal skilled worker program, your occupation must appear on the following list:
http://www.cic.gc.ca/english/immigrate/skilled/complete-applications.asp
If your occupation does not fall under the following list or if it does but that category has hit the cap - you will need a job offer in Canada to apply to immigrate. The cap is reset each year. If you are interested in NOC 1122, you should be aware that this occupation reached its cap in 7 days this year (i.e. cap was reset July 1st and 500 applications were received by July 7th). If this occupation remains on the list for 2012, everyone is expecting it to cap even faster.
The provincial nominee programs have different requirements and you'll have to research each of these independently. Information can be found here:
http://www.cic.gc.ca/english/immigrate/index.asp
Finally, note that you will have to take a language test as part of this process (it's mandatory for applicants regardless of their country of origin).