Well, according to Manitoba's PNP site : http://www.immigratemanitoba.com/how-to-immigrate/mpnp-news/
You have to have been working in Manitoba for a Manitoba employer for 1 year to apply for their PNP.
I haven't found anything that says your program must be related to your job. But I could be wrong.
For Canadian Experience Class, your job, from what I recall MUST be related to your program, furthermore it must be NOC 0, A, B which is listed in the site I posted earlier, I believe.
Look, the safest thing for you is to find employment in a job related to your program, but there must be a reason why you're asking this...