Yes - you can certainly submit an Express Entry profile. To be selected out of the FSW pool of candidates, you will want to have 470+ points. Have you calculated how many points you have?
Also note that you will need to complete a language test and have your education assessed before you can submit a profile for consideration.
I doubt it would be close to 470, in which case you should look into ways to improve (learn French, find a job supported by an LMIA, get a provincial nomination, consider further education in Canada, etc.)
How do I get a provincial nomination? I have an EE score of 438, a band 8 IELTS I'm looking at NS PNP category B but its closed at the moment. Any idea when it will be open pls?
Nobody knows when a province will open a stream. You can compare all of them here. The best way to get a nomination is find an open stream you qualify for.