Under the federal program, only if you have no other relatives in Canada and no other closer relatives alive that you could sponsor such as parents, see http://www.cic.gc.ca/english/immigrate/provincial/apply-who.asp
Under a PNP only if you live in a province that has a family stream component, such as AB, SK and MB. See http://www.cic.gc.ca/english/immigrate/provincial/apply-who.asp