"If the candidate does not respond to the ITA (i.e., the candidate does not submit a complete APR within 60 calendar days of receiving the ITA and does not formally decline the ITA within this delay), the ITA will expire and the candidate will no longer be in the Express Entry pool. To re-enter the pool, the candidate must submit a new profile in their online account and be assessed for the MEC at that time." https://www.canada.ca/en/immigratio...residence/express-entry/invitation-apply.html