Absolutely not, some will tell you it might slow down your application if you have an AOR ongoing but it has absolutely no effect whatsoever now with COVID..
I am am AOR April 6th, 2020 , I have left my job as did my wife ( Both applicants in the same application), and we moved to immigrate to another country more than 6 months ago, all we did is to update IRCC aboutthe situation gave our new address and submitted our residence cards and new employment contracts thats all, but in practices all you have to do is notify them and submit your new contact info and address thats all.