Number of tries does not matter much. As long as you have a genuine case (not a made up case) visa officer will review your case normally. (of-course in your case he may dig more than usual applications)
By genuine I mean, your academic background matches with your desired program in CA. Your work-experience makes sense with the degree you're planning to pursue. Your ties to your native country (family, business, STABLE JOB, money, taxes etc). etc
The most important one in my opinion is: your previous academic background+previous job+desired degree/
Good luck.