No, you can not "cancel" it, only CIC can do that. Since it is a spousal work permit, it is valid as long as you guys are still married or common-law. If you seperate or divorce and inform CIC, then they may or may not cancel the spousal work permit.
Note that your spouse can also get a work permit that is separate from you(through LMO from employer) and even if you divorce, she/he can still remain in Canada legally.