Regarding cic it's OK if you want to apply from Quebec as soon as you have the *intention* to reside in an other province *after* getting the pr. Approved.
In my case I already moved with a new address and got an inscription in a school in Ottawa .....saying this cause you have to prove your ties with the province you r going to . It doesn't matter if you were living in Quebec , some people living in Alberta but they did their master degree in Quebec and they were asked to provide a letter of intention . , personally I have the screen shot of one person who got refused because au Quebec but the reason was so obvious ,,,,,she was in the us Seattle the applied for THE PROVINCE BC during the process she got a locked work permit with lmia from Quebec employer and she moved to Montreal ...result rejection cause she provided the pays tubs and info about the new employer.
For me this is a good reason and not because you lived in Quebec ....Ontario is like 45min from Quebec so it's easy to go .
Anyway in this topic please if anyone got any info share it with us with some accurate details and the exact reason of rejection as mentioned by the agent.