You can re-enter the pool if you are still eligible. You don't have to create the profile from scratch, but you can update information like IELTS scores, work information etc.
There are some provinces such as Alberta, Ontario that nominate candidates in the EE pool based on their own criteria. For others such as Saskatchewan, Manitoba, PEI etc you need to submit expression of interest to their PNP program. Please visit the website of each province for more info. https://www.canada.ca/en/immigratio...migrate-canada/provincial-nominees/works.html
All the best!