SINP - Which ECA is Required for NOC 2221 (Microbiologist)

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I am Microbiologist. I want to apply in SINP. My Noc is 2221 which comes under licensed and regulated occupation. I don't understand which ECA SINP will accept for NOC 2221.

Can I provide same ECA done for Express Entry OR SINP accept course by course OR document by document ECA. Do I need to upgrade or NOT?

Can I apply without upgrading?

PLEASE HELP ME ANYBODY............