I am not too educated on the process, so if anyone else wants to correct me be my guest. I have only just sent out my PNP application for Ontario (no canadian work exp.).
I don't think it matters what province you have work experience in as long as you have the relevant Canadian work exp. Did you get the Letter of Interest from Ontario? If so you can go ahead and apply. You will have to show ties in Ontario for submitting letter of intent to reside there.