Hi,
1.For visa office u shd apply to London Office ,as it is the immigration office dealing to all of Gulf immigration cases, instead of ISD,as ISD ll take atleast 2-3 yrs more than London to process ur case.
2.U can put any city,town as ur destination in ur form, but Calgary or any other place in Alberta ll be a better option for u,but its not nessary tht one shd land on the same mentioned place when he gets his PR.
3.for proof of Funds it depends upon no. of persons included in the application , so plz visit
www.cic.gc.ca ,for exact details abt supporting funds.
4.As ur applying outside Buffalo office, so u ve to apply thru Simplified Application process , in which u just ve to submit just the basic form, IMM008,in tht form u ve to include details of ur dependents,wife kids,but as ur process will proceed ,they ll ask u for more forms n in those forms u ll ve to submit details of ur rest of family, no matter they r accompanying u or not.U can download the form from
www.canada.org.uk.
hope this helps, if u ve any other qs , i ll be pleased to answer.