It is not a problem if their are two PA who are applying at the same time with dif. VO?
No, there are no rules against it. When the rules for skilled worker were changed initially with the old list of 38 and aiming for shorter processing times, there was a lot of talk about if it was allowed for the same person to apply under the new system even if you had an application under the old one and it was concluded that CIC does not have any rules saying that you can not have many applications going. There have been people doing that and there have been people applying under PNP and FSW at the same time. If CIC is at the point that they want you to withdraw one of them because the other is moving forward, they can ask you to do it. You of course have paid double processing fees so why should they care.
As for a husband and wife applying separately with each other as dependent, that is absolutely no problem at all. I believe it was even asked and answered in the skilled worker FAQ at some point but they update the FAQ regularly, taking out old questions and replacing them so it doesn't get too big.