best chances for your sister? wait until you have PR and move to Manitoba

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Yes it can cause problems in the way that the officers may doubt, that your sister really will stay in Manitoba (which the PNP's are all about). I don't have any experience as such with it, but am helping as immigration/settlement officer...and that's what we are getting told. She will find a very valid reason to prove that she will stay in MB (job offer could help).