Did you sign anything stating that you are going to stay in Manitoba for X years?
If you applied through Manitoba PNP, there is normally just a letter of intent to settle where you sign that you intend to settle in Manitoba and this must be true when you land. If you have lived in Manitoba for 10 months but not had much luck finding a good job etc. nobody can say that you did not intend to settle at the time you landed and try to settle for the 10 months you have already been there so you have really nothing to worry about if you move.
When I applied for BC PNP nomination, I showed my intent to settle in BC through what I'm involved with right now. However, that's just an intended outcome, not necessarily a legally bound and enforced one. Conditions may changed due to major forces, such as your doctor advises you to reside in Halifax for whatever reason...
If your intentions are pure and you have to move, then go for it, since you've got nothing to be afraid of. However, if you're manipulating the system by dishonestly claiming unintended outcomes, then there exists a probability haze in which you may live in some sort of natural fear