I am a US citizen my self but I am a tad bit coufused of the exact question you are asking?
If you change "centrally located in Canada" to "with a Canadian employer," it becomes clearer.
She's asking whether working for her U.S. employer will qualify her for PNP nomination since she can do her job from anywhere.
The PNP program is supposed to attract workers to Canada who will work for Canadian companies - not U.S. employees who want to live in Canada without providing any benefit to the workforce.